1H-pyrazol-5-amine, 3-(4-pyridinyl)-

1H-pyrazol-5-amine, 3-(4-pyridinyl)- - Names and Identifiers

Name	3-(pyridin-4-yl)-1H-pyrazol-5-amine
Synonyms	3-Amino-5-(4-pyridyl)-1H-pyrazole 5-PYRIDIN-4-YL-2H-PYRAZOL-3-YLAMINE 5-(pyridin-4-yl)-1H-pyrazol-3-aMine 3-(pyridin-4-yl)-1H-pyrazol-5-amine 5-(4-pyridinyl)- 1H-Pyrazol-3-amine 1H-pyrazol-5-amine, 3-(4-pyridinyl)- 3-Amino-5-(pyridin-4-yl)-1H-pyrazole 1H-Pyrazol-3-amine, 5-(4-pyridinyl)-
CAS	91912-53-7
InChI	InChI=1/C8H8N4/c9-8-5-7(11-12-8)6-1-3-10-4-2-6/h1-5H,(H3,9,11,12)

1H-pyrazol-5-amine, 3-(4-pyridinyl)- - Physico-chemical Properties

Molecular Formula	C8H8N4
Molar Mass	160.18
Density	1.315±0.06 g/cm3(Predicted)
Melting Point	192-193 °C
Boling Point	465.4±35.0 °C(Predicted)
Flash Point	266.32°C
Vapor Presure	0mmHg at 25°C
pKa	13.12±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.674

1H-pyrazol-5-amine, 3-(4-pyridinyl)- - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

1H-pyrazol-5-amine, 3-(4-pyridinyl)- - Introduction

3-(pyridin-4-yl)-1H-pyrazol-5-amine is an organic compound with the chemical formula C9H8N4.

Nature:
-Appearance: 3-(pyridin-4-yl)-1H-pyrazol-5-amine is a colorless to light yellow crystal or powdery solid.
-Solubility: It can be dissolved in some organic solvents, such as methanol, ethanol and dimethyl sulfoxide.
-Melting point: Its melting point is 185-187°C.

Use:
3-(pyridin-4-yl)-1H-pyrazol-5-amine is a potential pharmaceutical intermediate, which may have anti-tumor, anti-inflammatory and anti-viral activities in the field of medicine. It can be used as a synthetic raw material in drug development.

Method:
A common preparation method is synthesis by hydrogen reduction.
First, 4-pyridinecarboxamide is reacted with 1-amino-3-azepinylformamidine under basic conditions to generate 3-(pyridin-4-yl)-1H-pyrazol-5-amine. Then, the pure product can be obtained by recrystallization or other separation and purification methods.

Safety Information:
3-(pyridin-4-yl)-1H-pyrazol-5-amine has limited toxicity and hazard data, but as an organic compound, the following matters should be paid attention to when handling:
-Avoid inhalation, contact with skin or ingestion. Wear suitable protective gloves, safety glasses and protective mask during operation.
-Avoid contact with oxidants, strong acids and strong bases to prevent dangerous reactions.
-should be operated in a well-ventilated place to avoid producing a large amount of gas, vapor or smoke.
-Keep away from fire or high temperature environment during use or storage.

In general, for the use and handling of chemicals, it is recommended to follow safe operating procedures and laboratory safety guidelines, and implement personal protective measures according to specific conditions.

Last Update：2024-04-09 21:01:54